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RE: NONMEM compiler

From: Adams, Jeb <jeba>
Date: Thu, 15 Mar 2012 15:47:59 -0700

My concerns with the Polyhedron website’s numbers are the use of gfortran 4.1.2 which was published in February of 2007 and gfortran 4.44 [sic] from April 2010 for the Linux computing environment comparisons. The Intel compiler is always from August 2011, which would align it with gfortran 4.6.1.

As noted though, the transition from 32-bit to 64-bit is a much bigger impact on runtime than Intel v gfortran.

Jeb Adams, Research Operations Manager
PKDM IS Liaison
Amgen, Inc.

From: [] On Behalf Of Mark Sale - Next Level Solutions
Sent: Thursday, March 15, 2012 4:31 AM
To: 'nmusers'
Subject: RE: [NMusers] NONMEM compiler

   The web site that Oskar posted seems extremely useful, and confirmed the rumors that have been around for awhile.  But, I'm wondering why anyone would use 32 bit, when 64 bit is faster (about 20%) and seems to be better behaved numerically?


Mark Sale MD
President, Next Level Solutions, LLC
A carbon-neutral company
See our real time solar energy production at:

-------- Original Message --------
Subject: Re: [NMusers] NONMEM compiler
From: Oskar Clewe <>
Date: Wed, March 14, 2012 10:16 am
To: "Gieschke, Ronald" <ronald.gieschke>, "'nmusers'"

Dear Ronald
To my understanding the IVF is considered to be somewhat faster than the gfortran compiler in general. But gfortran is on the other hand open source. Regarding "quality" I think it is more dependent upon model than compiler. Here are some non NONMEM related compiler benchmarks

Kind Regards
-- Oskar Clewe, MSc Pharm PhD Student Pharmacometrics Research Group Department of Pharmacutical Biosciences Uppsala University P.O. Box 591 751 24 Uppsala SWEDEN

On 2012-03-14 13:34, Gieschke, Ronald wrote:
Dear nmusers,
Do you have any recommendations regarding gfortran and Intel Visual Fortran under 32 bit Windows 7?  Are runtimes and quality (e.g. covariance step successful) comparable?
Many thanks for your response in advance.  

Received on Thu Mar 15 2012 - 18:47:59 EDT

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