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Next Rosa Impact Webinar

From: Toufigh Gordi <tgordi>
Date: Tue, 27 Mar 2012 10:25:23 -0700

Using mathematical models to set design criteria for antibody-based
Dr. Birgit Schoeberl
Vice President of Discovery
Merrimack Pharmaceuticals
April 17, 2012
1:00 - 2:00 pm EDT
Monoclonal antibodies are valuable as anticancer therapeutics because of
their ability to selectively bind tumor-associated target proteins like
receptor tyrosine kinases. However, most tumors are addicted to more than
one pathway which asks for rational antibody combinations or bispecific
antibodies. In our presentation, we will illustrate the use of kinetic
computational models that capture protein≠protein interactions to explore
antibody combinations vs. bispecific antibodies, different formats of
bispecific antibodies, to set antibody design specifications such as
affinity and valence, and to predict potency.

The purpose of the ≥Impact≤ series is to foster the use of M&S activities i=
all phases of drug development by illustrating the advantages and enhancing
the applicability of M&S in product discovery, development, and marketing
programs. The series is intended for drug development project team members
from discovery to phase 4 clinical trials. This includes pharmacologists,
ADME scientists, PK/PD modelers, clinical pharmacologists, clinical
development team members, regulatory affairs specialists, and other
interested professionals.
Register for this free webinar at
<> . After registering you will receive a
confirmation email containing information about joining the webinar. More
information about the webinar series, an archive of past webinars, and a
list of future webinar speakers may be found at
<> .
Please allow 5-10 minutes for a Java applet to be installed on your compute=
prior to joining our webinar series for the first time.
Toufigh Gordi, PhD
President, PK/PD and Clinical Pharmacology Services
Rosa & Co. LLC: <>
E-mail: tgordi
Tel.: 408-480-7314
Fax: 408-370-9810

Received on Tue Mar 27 2012 - 13:25:23 EDT

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