NONMEM Users Network Archive

Hosted by Cognigen

unusual SAEM crash

From: nonmem
Date: Sat, 17 Nov 2012 10:34:55 +0000 (GMT)

Hello NONMEM Users,

As SAEM looks like a fast alternative to some other methods, I tried it many times as a stratup method. It worked well except for one imortant occasion when NONMEM crashed without any written warnings. A pop-up message was saying "nonmem.exe has stopped working." The *.out file looks as follows:


 GENERAL NONLINEAR KINETICS MODEL USING LSODA (ADVAN13)
0MODEL SUBROUTINE USER-SUPPLIED - ID NO. 9999
0MAXIMUM NO. OF BASIC PK PARAMETERS: 14
0COMPARTMENT ATTRIBUTES
 COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT
                         STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
    1 C1 ON YES YES YES YES
    2 C2 ON YES YES NO NO
    3 C3 ON YES YES NO NO
    4 C4 ON YES YES NO NO
    5 C5 ON YES YES NO NO
    6 C6 ON YES YES NO NO
    7 C7 ON YES YES NO NO
    8 C8 ON YES YES NO NO
    9 C9 ON YES YES NO NO
   10 C10 ON YES YES NO NO
   11 C11 ON YES YES NO NO
   12 OUTPUT OFF YES NO NO NO
0NRD VALUE(S) FROM SUBROUTINE TOL: 5
1
 ADDITIONAL PK PARAMETERS - ASSIGNMENT OF ROWS IN GG
 COMPT. NO. INDICES
              SCALE BIOAVAIL. ZERO-ORDER ZERO-ORDER ABSORB
                         FRACTION RATE DURATION LAG
    1 * 17 * * *
    2 * 18 * * *
    3 15 * * * *
    4 * * * * *
    5 * * * * *
    6 * * * * *
    7 16 * * * *
    8 * * * * *
    9 * * * * *
   10 * * * * *
   11 * * * * *
   12 * - - - -
             - PARAMETER IS NOT ALLOWED FOR THIS MODEL
             * PARAMETER IS NOT SUPPLIED BY PK SUBROUTINE;
               WILL DEFAULT TO ONE IF APPLICABLE
0DATA ITEM INDICES USED BY PRED ARE:
   EVENT ID DATA ITEM IS DATA ITEM NO.: 10
   TIME DATA ITEM IS DATA ITEM NO.: 4
   DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 5
   DOSE RATE DATA ITEM IS DATA ITEM NO.: 7
   COMPT. NO. DATA ITEM IS DATA ITEM NO.: 11
   PRED. COMPT. DATA ITEM IS DATA ITEM NO.: 12
0PK SUBROUTINE CALLED WITH EVERY EVENT RECORD.
 PK SUBROUTINE NOT CALLED AT NONEVENT (ADDITIONAL OR LAGGED) DOSE TIMES.
0PK SUBROUTINE INDICATES THAT COMPARTMENT AMOUNTS ARE INITIALIZED.
0ERROR SUBROUTINE CALLED WITH EVERY EVENT RECORD.
0DES SUBROUTINE USES FULL STORAGE MODE.
1

 #TBLN: 1
 #METH: Stochastic Approximation Expectation-Maximization
 EM/BAYES SETUP
 THETAS THAT ARE MU MODELED:
   1 2 3 4 5 6
 THETAS THAT ARE SIGMA-LIKE:
 
 MONITORING OF SEARCH:
Stop Time:
Sat 11/17/2012
05:25 AM

When I tried Bayes, the program did not crash, but the method did not converge well.

Is there any way to fix the SAEM run? What can cause this crash?

Thanks,
Pavel

Received on Sat Nov 17 2012 - 05:34:55 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.