NONMEM Users Network Archive

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time-to-event simulation based diagnostic

From: Francois Gaudreault <f_gaudreault11>
Date: Wed, 19 Sep 2012 20:48:54 +0000


Dear NONMEM users

I am currently performing a time-to-event analysis on binary data using a w=
eibull distribution (time-varying hazard function).

Using simulation based diagnositcs, I compared `simulated kaplan-Meier` t=
o `observed kaplan-Meier`. However, fit looks to good to be true and I wa=
s actually suspecting a mispecification during the simulation process with =
PsN


Here is the code used for vpc:

vpc run2.mod -tte=RTTE -flip_comments -samples=100


I used (ICALL.EQ.4) and the flip-comment option in the model file. However=
, I am not sure if I have to generate a new simulation data set (each ind=
ividual having a row for each possible observation time) or use the origina=
l one ?

Any advises or comments are welcome

Regards,

--





François Gaudreault, Ph.D. Candidate
Pharmacométrie / Pharmacometrics
Chargé de cours / Lecturer
Faculté de pharmacie / Faculty of Pharmacy
Université de Montréal

                                               =

Received on Wed Sep 19 2012 - 16:48:54 EDT

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