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Bootstrap, re-using inital model run results

From: Lommerse, JPM <jos.lommerse>
Date: Thu, 14 Feb 2013 08:29:13 +0100


I would like to ask to NONMEM community whether it is possible to re-use the results of a nonmem model run when starting bootstrapping.
As I understand, a bootstrap run using PsN starts with a single calculation of the model of interest and data set as is. Once this initial model run
has completed, the actual bootstrapping starts by sampling from the initial data set to the requested number of samples.
However, the initial run often has been carried out already, and the bootstrap method this seems to be repeated.

I am dealing with a rather time consuming model / data set. Therefore I was wondering whether it is possible the re-use the results of a nonmem
model run and start the bootstrapping directly without repeating this initial nonmem model run. I was not able to find any option to do so. Perhaps there
is way around?



Jos Lommerse
Assoc. Prin. Scientist, Quant. Sciences
Clinical PK-PD
T: +31 412 661456
F: +31 412 662555

Molenstraat 110, 5342 CC Oss
PO Box 20, 5340 BH Oss
The Netherlands

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Received on Thu Feb 14 2013 - 02:29:13 EST

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