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M3 method and multiple LOQ values

From: Rebecca N. Burns <burns_rn>
Date: Thu, 7 Mar 2013 11:46:01 -0500

All,

I am implementing the M3 method using NONMEM7.2. My error structure is pro=
portional. I have two questions regarding the control stream shown below.


1. Is the control stream correct for a proportional error model?

2. Each DV has its own LOQ so I cannot give one LOQ value. I was pla=
nning to assign a column in my data frame which defines LOQ for each DV. =
Is this an appropriate approach?

Any input/advice would be much appreciated!

Thanks,

Rebecca Neal Burns, PharmD, PhD
Post-Doctoral Scholar, Pharmacometrics
Mercer University, Atlanta, GA

$ERROR

SIG=THETA(4)
IPRED=F
LOQ=LLOQ
DUM=(LOQ-IPRED)
CUMD=PHI(DUM)

IF (BQL.EQ.0) THEN
F_FLAG=0
Y=IPRED*(1+SIG*ERR(1))
ENDIF

IF (BQL.EQ.1) THEN
F_FLAG=1
Y=CUMD
ENDIF

$EST METHOD=COND INTER LAPLACIAN
$SIGMA 1 FIX



Received on Thu Mar 07 2013 - 11:46:01 EST

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