NONMEM Users Network Archive

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Genotype data missing in some individuals

From: 이소정 <sjlpharm>
Date: Wed, 19 Nov 2014 15:21:27 +0900

Dear all,

 

I’ve analyzed a tacrolimus PopPK in pediatric patients.

As you know, CYP3A5 genotype can change the tacrolimus PK significantly, =
3A5 genotyping was performed in the study,

however, in 20% of the subjects, the genotype data was missed.

 

Then, how can I reflect the CYP3A5 genotype effect to the tacrolimus =
population model appropriately?

Is there any solution?

 

Best regards,

SoJeong Yi

 


Received on Wed Nov 19 2014 - 01:21:27 EST

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