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From: Chiaying Lin <cylin292_at_gmail.com>
Date: Tue, 25 Aug 2015 09:16:22 +0800

Dear NM-Users,
I'm a NONMEM beginner. The following are my control stream for a monoclonal
antibody which clears via target mediated disposition. However, when I ran
NONMEM, I didn't get minimization successful message (in fact, no message
at all), there are also no Table output and the xx.g77 file contains only
empty three output files. I will be appriciated if someone help
to find mistakes. Thanks.

Peggy

---------------------------------------------------------------------------=
------------------------------------------------------------
$PROBLEM **base model**

$DATA PKDATA.CSV IGNORE=C

$INPUT ID TIME AMT NDV=DROP LNDV=DV EVID MDV CMT BW AGE DOSE

$SUBROUTINE ADVAN6 TRANS1 TOL=3

$MODEL NCOMP=2 NPAR=6
;COMP=(CENTRAL DEFOBSERVATION DEFDOSE)
;COMP=(PERIPH)

$PK
TVVMAX=THETA(1)
VMAX=TVVMAX*EXP(ETA(1))
KM=THETA(2)
TVV1=THETA(3)
V1=TVV1*EXP(ETA(2))
TVV2=THETA(4)
V2=TVV2*EXP(ETA(3))
Q=THETA(5)*EXP(ETA(4))
S1=V1

$DES
C1=A(1)/V1
C2=A(2)/V2
DADT(1)=-VMAX*C1/(KM+C1)-(Q*C1)+(Q*C2)
DADT(2)=(Q*C1)-(Q*C2)

$ERROR
CALLFL=0
IPRED=LOG(F)
IRES=DV-IPRED
IWRES=IRES/IPRED
Y=IPRED+ERR(1)

$THETA
(0.1, 1.49, 5) ;VMAX (mg/hr)
(1, 50,300) ;KM (μg/mL)
(1.3, 2.72, 5) ;V1 (L)
(1.1, 2.43, 5) ;V2 (L)
(0.001, 0.095, 1) ;Q (L/hr)

$OMEGA .025 ;VMAX
$OMEGA .032 ;V1
$OMEGA .29 ;V2
$OMEGA .975 ;Q

$SIGMA
0.030 ;ERR(1)

$ESTIMATION METH=1 MAXEVAL=9999 PRINT=5 POSTHOC

$COVARIANCE
$TABLE ID TIME DV IPRED IWRES VMAX KM V1 V2 Q ETA1 ETA2 ETA3 ETA4 BW AGE
NOPRINT ONEHEADER FILE=1.fit
$TABLE ID TIME AMT IPRED IWRES NOPRINT ONEHEADER FILE=sdtab1
$TABLE ID VMAX KM V1 V2 Q ETA1 ETA2 ETA3 ETA4 NOPRINT ONEHEADER FILE=pata=
b1
$TABLE ID BW AGE NOPRINT ONEHEADER FILE=cotab1
---------------------------------------------------------------------------=
-------------------------------------------------------
#IDTIMEAMT


NDV



LNDV


EVIDMDVCMTBWAGEDOSEA-P001081.3..11181.35081.3A-P0010.254.81.568616181.350
81.3A-P0011182.890372181.350

81.3


   LNDV=Ln-transformed
con. (mcg/ml)

Received on Mon Aug 24 2015 - 21:16:22 EDT

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