NONMEM Users Network Archive

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RE: [NMusers] Simulo: a new service for drug trial simulation

From: Michael Fossler <mfossler_at_trevenainc.com>
Date: Tue, 23 Jun 2015 18:30:12 +0000

Does anyone have an example of using Fn (bioavailability of compartment n) =
to do adaptive dosing simulations? I am not having much luck getting it to =
work.


Mike
Michael J. Fossler, Pharm. D., Ph. D., F.C.P.
VP, Quantitative Sciences
Trevena, Inc
mfossler_at_trevenainc.com
Office: 610-354-8840, ext. 249
Cell: 610-329-6636


-----Original Message-----
From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Mats Karlsson
Sent: Tuesday, June 23, 2015 12:06 PM
To: Leonid Gibiansky; Faelens, Ruben (Belgium); nmusers_at_globomaxnm.com
Subject: RE: [NMusers] Simulo: a new service for drug trial simulation

Hi,

In many cases you don't even need to use $ABB COMRES to do response-adaptiv=
e designs, simulated response could just impact a bioavailability term (Fx)=
 of the next dose(s) to indicate dose change. I'm sure that more complex re=
sponse-adaptive designs could benefit from a dedicated software though.

Best regards,
Mats


Mats Karlsson, PhD
Professor of Pharmacometrics

Dept of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
Box 591
75124 Uppsala

Phone: +46 18 4714105
Fax + 46 18 4714003
www.farmbio.uu.se/research/researchgroups/pharmacometrics/

-----Original Message-----
From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On=
 Behalf Of Leonid Gibiansky
Sent: Tuesday, June 23, 2015 4:14 PM
To: Faelens, Ruben (Belgium); nmusers_at_globomaxnm.com
Subject: Re: [NMusers] Simulo: a new service for drug trial simulation

Actually, nonmem can be used to simulate the response-based dose adaptation=
 without iteratively rerunning your model, with single simulation (using $A=
BB COMRES functionality to pass simulated response to the dose-adjustment a=
lgorithm code), although it is indeed cumbersome

Leonid

--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566



On 6/23/2015 4:48 AM, Faelens, Ruben (Belgium) wrote:
> Dear NONMEM users,
>
> We all know how difficult it is to simulate full drug trials using
> NONMEM. It is often necessary to generate the full dosing scheme(s)
> beforehand, and response-based dose adaptation requires iteratively
> rerunning your model until you have the results you are happy with.
>
> At SGS Exprimo, we have been working for 4 years to develop a new
> software that makes drug trial simulation much more straight-forward.
> The software has been developed in collaboration with Roche and has
> been used internally within SGS Exprimo for the last 2 years. We are
> now presenting it to the public as a new consultancy service. You may
> have seen us in Crete at PAGE 2015.
>
> We invite you to visit our website www.simulo.eu
> <http://www.simulo.eu> or contact us directly to request an on-site
> demo or web conference, or to ask any questions you may have.
>
> We look forward to hearing from you.
>
> Kind regards,
>
> Ruben Faelens for SGS Exprimo
>
> *Ruben Faelens, MSc*
> *Life Science Services - Exprimo*
> IT Scientist
>
> Phone:
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> +32 494 06 72 59
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> E-mail:
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> _ruben.faelens_at_sgs.com <mailto:ruben.faelens_at_sgs.com>_
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> Web:
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> www.exprimo.com <http://www.exprimo.com/>
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Received on Tue Jun 23 2015 - 14:30:12 EDT

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