NONMEM Users Network Archive

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Re: [NMusers] scm problem

From: Ron Keizer <ronkeizer_at_gmail.com>
Date: Wed, 27 May 2015 16:06:15 -0700

hi Muhammad,

a brief guidance on how to do a stepwise covariate search with PsN+Pirana
is given in our recent tutorial in CPT-PSP (
http://onlinelibrary.wiley.com/doi/10.1038/psp.2013.24/abstract), in which
we used the scm tool in PsN, and Pirana to generate the scm config file.
Let me know if you don't get the example to run. (Someone reported recently
that the appendix files were not available anymore, but they are also here:
https://github.com/ronkeizer/ppx_tutorial)

Of course—if you keep having trouble getting the scm tool to runâ=
€”you could
choose to implement and run the covariate models manually: for only five
covariates there is only little gain in using the scm tool. A gentle
introduction on how to build covariate models in NONMEM is available in
chapter 5.7 of the recent book by Owen and Fiedler-Kelly (
http://www.amazon.com/Introduction-Population-Pharmacokinetic-Pharmacodynam=
ic-Nonlinear/dp/0470582294/
).

best regards,
Ron

PS. any Pirana-specific questions can also be posted at
http://qa.piranasoftware.com


On Wed, May 27, 2015 at 6:35 AM, Muhammad Usman <usman.ips_at_gmail.com> wrote=
:

> Dear NMUsers
> I am a beginner with NONMEM. I have developed a model and want to use AGE=
,
> WT, CRCL, SeCR and SEX as covariates on CL, V1 and V2. Can someone provid=
e
> me the step by step guidence how can I perform this Analysis by using
> Pirana?
>
> Regards
>
> --
> *Muhammad Usman*
> PhD Scholar
> Westfälische Wilhelms-Universität Münster
> Institut fĂĽr Pharmazeutische und Medizinische Chemie
> - Klinische Pharmazie -
> Corrensstrasse 48
> 48149 MĂĽnster
>
> Room No. A120.209
>
> Phone: +49 251/8332171
>
> Mob # +49 176 70962067
>

Received on Wed May 27 2015 - 19:06:15 EDT

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