NONMEM Users Network Archive

Hosted by Cognigen

Re: [NMusers] Incorporating standard deviation (SD) on fitted mean values

From: Paul Matthias Diderichsen <pmdiderichsen_at_wequantify.com>
Date: Thu, 19 Nov 2015 16:49:09 +0100

On 11/19/2015 9:58, Nick Holford wrote:
> Some of the RUV arises from within study between subject variability
> in A and ALPHA and some from the usual sort of RUV (model
> misspecification, measurement error, stochastic noise, etc)

Agree.

In this case, I don't think it matters where the variability comes from.
It's part of the data, with each reported outcome defined by c(mean,sd).
sd incorporates both between- and within-subject variability. Separating
BSV and WSV is tricky when only aggregate data is available.

--
Paul Matthias Diderichsen, PhD
Quantitative Solutions, a Certara company
+31 624 330 706
Received on Thu Nov 19 2015 - 10:49:09 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com. Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.