NONMEM Users Network Archive

Hosted by Cognigen

RE: mu coding for variability in SD

From: Bauer, Robert <Robert.Bauer>
Date: Fri, 20 Nov 2015 21:07:55 +0000

If your theta=SD’s will have etas, no need for TS() specification. You should not need to put in the GRD statement at all, then. (The TG() is to force Gibbs sampling in BAYES methods)


Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics R&D
ICON Early Phase
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer om<mailto:Robert.Bauer
www.iconplc.com<http://www.iconplc.com>

From: owner-nmusers [mailto:owner-nmusers
Sent: Friday, November 20, 2015 12:31 PM
To: nmusers
Subject: [NMusers] mu coding for variability in SD

Hello The NONMEM Professionals,

The model requires SAEM. Is mu coding useful when each subject has to have different SD (SDi=SD0*exp(etai))?

It may look something like

MU_8 =THETA(8)
SD = DEXP(MU_8 +ETA(8))

$THETA (0.00001,0.0413,50) ;SD1
$THETA (0.001 FIX) ;SD2

GRD=TG(1-9) ;(instead of GRD=TG(1-7):TS(8-9))

Thanks!
Pavel
<br /><br />
ICON plc made the following annotations.
------------------------------------------------------------------------------
This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you
are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If
you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message.

Thank You,

ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835
Received on Fri Nov 20 2015 - 16:07:55 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com.

Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.