NONMEM Users Network Archive

Hosted by Cognigen

Re: [NMusers] BLQ Data

From: Ahmed Suleiman <>
Date: Fri, 2 Oct 2015 18:05:36 +0200

Hi Brady,

Have a look at this recently published paper by Ron Keizer and colleagues;
will answer your question.

"Incorporation of concentration data below the limit of quantification in
population pharmacokinetic analyses". Keizer et al, Pharmacol Res Perspect,

Best Regards,

On Fri, Oct 2, 2015 at 4:22 PM, Moffett, Brady S. <> wrote=

> I am working with TDM data and am wondering when to use the M3 method for
> dealing with BLQ data, or, when to just exclude data?
> For instance: If I have <1% BLQ data in a large dataset (~1000 patients)=
> should I just exclude those patients/values? If I just have one patient
> with one value BLQ, is it worth using the M3 method for that one patient?
> Is there a breakpoint for which using these methods does/does not make a
> difference?
> Thanks in advanceā€¦
> ______________________________________________________________________
> The information in this e-mail may be confidential and/or
> privileged. If you are not the intended recipient or an
> authorized representative of the intended recipient, you
> are hereby notified that any review, dissemination, or
> copying of this e-mail and its attachments, if any, or
> the information contained herein is prohibited. If you
> have received this e-mail in error, please immediately
> notify the sender by return e-mail and delete this e-mail
> from your computer system. Thank you.
> ______________________________________________________________________

Ahmed Abbas Suleiman, MSc
PhD Candidate at Bonn University
Institute of Pharmacology - Clinical Pharmacology Unit
Hospital of the University of Cologne
Gleueler Str. 24, 50931 Cologne,

Received on Fri Oct 02 2015 - 12:05:36 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: Once subscribed, you may contribute to the discussion by emailing: