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RE: [NMusers] forest plots in Xpose?

From: amit <amitvtaneja_at_hotmail.com>
Date: Sun, 11 Oct 2015 01:50:40 +0530


Dear all,

As a late entrant to this discussion, indeed there are many ways to Rome.

The dotplot function in R (lattice) could provide a similar visual output=
, though not as elegant as the Metrum approach.The metrumrg package is n=
ot available on the CRAN repository any longer, but on R forge.

best wishes

Amit Taneja

Research fellow, Pharmacometrics

Dept of Pharmacokinetics, Toxicology and Targeting

University of Groningen

The Netherlands



> From: pascal.girard_at_merckgroup.com
> To: pmdiderichsen_at_wequantify.com; nmusers_at_globomaxnm.com
> Subject: RE: [NMusers] forest plots in Xpose?
> Date: Fri, 18 Sep 2015 20:51:20 +0000
>
> Dear All,
>
> Thanks all for your replies. I will not reply to each. Just to say that o=
f course I know that forest plots come from Meta Analysis, which by the w=
ay may be already familiar to clinicians.
>
> It has been advocated by FDA to report DDI see (Menon-Andersen D, Yu B=
, Madabushi R, Bhattaram V, Hao W, Uppoor RS, Mehta M, Lesko L=
, Temple R, Stockbridge N, Laughren T, Gobburu JV. Essential pharma=
cokinetic information for drug dosage decisions: a concise visual presentat=
ion in the drug label. Clin Pharmacol Ther. 2011 Sep;90(3):471-4. ) and =
is suggested in Guidance doc:
> http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformatio=
n/guidances/ucm292362.pdf
> http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterial=
s/Drugs/AdvisoryCommitteeforPharmaceuticalScienceandClinicalPharmacology/UC=
M370535.pdf
>
> I think it is an excellent way to communicate the results of covariate an=
alysis, rather than giving an allometric/ power equation and a value of a=
 parameter that does not speak to clinicians. I agree with Ron that it shou=
ld be clearly stated what is presented and there are several ways of buildi=
ng it. In this respect the one given in the slides of Marc Gastonguay (than=
ks Andreas) is particularly appealing.
>
> With best regards / Mit freundlichen Grüßen / Cordialement
>
> Pascal
>
> -----Original Message-----
> From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] =
On Behalf Of Paul Matthias Diderichsen
> Sent: 17 September 2015 09:12
> To: nmusers_at_globomaxnm.com
> Subject: Re: [NMusers] forest plots in Xpose?
>
> Ron, Pascal & NMUsers
>
> On 9/17/2015 2:08, Ron Keizer wrote:
> > On a sidenote, I'm not a fan of the term "Forest plot" for these plot=
s.
> > The "original" Forest plots show data across multiple studies (e.g. in
> > a meta-analysis), so calling it "Forest plot" could lead to confusion
> > with statisticians or clinicians.
>
> I agree with Ron that Forest plots primarily exist in the meta analysis w=
orld.
>
> Pascal, maybe you are looking for "tornado plots"?
> (https://en.wikipedia.org/wiki/Tornado_diagram)
>
> Here's a pointer to building a tornado plot with ggplot():
>
> http://stackoverflow.com/questions/6916698/tornado-chart-diagram-with-ggp=
lot2
>
> --
> Paul Matthias Diderichsen, PhD
> Quantitative Solutions B.V.
> +31 624 330 706
>
>
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Received on Sat Oct 10 2015 - 16:20:40 EDT

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