NONMEM Users Network Archive

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Re: [NMusers] Imputation of multiple categorical covariates with missing data

From: Ron Keizer <ron_at_pirana-software.com>
Date: Wed, 23 Sep 2015 09:23:30 -0700

hi Yassine,

There are alternatives to the mixture approach that would probably work
better in your case and can be used in the context of an scm too, see e.g.:

AAPS J. 2013 Oct;15(4):1232-41. doi: 10.1208/s12248-013-9526-y.
Comparison of methods for handling missing covariate data.
Johansson ├ůM, Karlsson MO.
(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787222)

AAPS J. 2012 Sep;14(3):601-11. doi: 10.1208/s12248-012-9373-2. Epub 2012
May 31.
Performance of methods for handling missing categorical covariate data in
population pharmacokinetic analyses.
Keizer RJ, Zandvliet AS, Beijnen JH, Schellens JH, Huitema AD.
(http://www.ncbi.nlm.nih.gov/pubmed/22648902)

best regards,
Ron

-------------------------------
Pirana Software & Consulting BV
_at_ronpirana

Received on Wed Sep 23 2015 - 12:23:30 EDT

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