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RE: [NMusers] ASCO and pharmacometrics

From: Joachim Grevel <>
Date: Wed, 6 Apr 2016 07:58:12 +0100

Dear Naoto,

Your experience is also mine. For a combined TTE safety and efficacy =
analysis I earned the online publication. The organisers do not believe =
in modelling, unless it describes what is already visible in graphs and =
tables of raw data.

This is just my personal impression. I have not been to ASCO either.


Good luck,




Joachim Grevel, PhD

Scientific Director

BAST Inc Limited

Science & Enterprise Park

Loughborough University

Loughborough, LE11 3AQ

United Kingdom


Tel: +44 (0)1509 222908 <>




From: [] =
On Behalf Of Naoto Hayashi
Sent: 06 April 2016 02:38
Subject: [NMusers] ASCO and pharmacometrics



Dear all,


I have a question and appreciate it if somebody can answer to me.


We had submitted an abstract to ASCO annual meeting presentation 2016, =
and its contents included a pharmacometrics work of quantitative safety =
profile analysis of an anticancer drug. The behave of the safety index =
time courses is very unique and its results showed a very high =
usefulness of this drug. The abstract also included the table of =
population PK/PD parameters that expressed its nature, and it was =
compared with the similar older drug safety profile and demonstrated =
very high safer profile quantitatively.


I have some experiences to publish some articles of population PK/PD =
work in several clinical pharmacology journals in the past, and I was so =
confident for just a poster presentation in ASCO. However, the judgment =
was “publication only”, i.e. just presentation in online =
but no poster presentation and no official record of publication =


So, my question is whether pharmacometrics work is difficult to be =
picked up in ASCO presentation. Or, was my work evaluated to have no =
worth to be presented even in poster session because the pharmacometrics =
works presented in ASCO are having very high level?


I have never visited ASCO before, and I just want to hear opinions about =
how much of importance is considered for pharmacometrics work in ASCO.


Thanks a lot in advance for your comments/thoughts.


Best regards,

Naoto Hayashi

Received on Wed Apr 06 2016 - 02:58:12 EDT

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