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NONMEM code verification

From: Ana Miranda Bastos <ana.bastos>
Date: Tue, 19 Jan 2016 22:14:55 +0000


I have a complex model with manually coded ODEs and multiple compartments. =
VPC etc seem ok but simulation results are getting a bit weird.

I'd like to find out what people use to ensure that the NONMEM code written=
 really represents the set of ODEs written on paper. Just to clarify, this =
is just to make sure the NONMEM instructions are actually a correct represe=
ntation of the mathematical description of the model, not if the model is a=
 correct representation of the biology at this stage.

This problem is not so obvious when you use the built-in macros but once th=
e model grows complex, and has a lot manual inputs, it is more likely that =
a bug creeps in.

I'm looking for something more stringent than a code review by a peer.

Thank you advance for your time and attention,


Ana Bastos, Pharm, MSc, PhD student
Pharmacologie cellulaire et moléculaire
(Cellular and Molecular Pharmacology Unit)
Louvain Drug Research Institute
Université catholique de Louvain (Catholic University of Louvain)
UCL 7370 avenue E. Mounier 73
1200 Bruxelles, Belgique

Received on Tue Jan 19 2016 - 17:14:55 EST

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