NONMEM Users Network Archive

Hosted by Cognigen

Re: Calculation of half life

From: Paolo Denti <paolo.denti>
Date: Wed, 30 Mar 2016 16:59:41 +0000

Dear Santosh,
there are formulas to make the conversions, and I normally use the spreadsheet that you can download at this link:

It is not very convenient If you want to do things in batches, but I guess you can do some "reverse engineering" and implement the code in NONMEM. I have done it for two-compartments, but I never needed it for three (which is a lot of coding).
If you do work out the NONMEM code - or anyone else already has it - please post it here, it could be useful.

Best regards,

On 2016/03/30 17:40, Santosh wrote:
Dear all,
I am looking for ways to calculate t[1/2,lamda,z] the elimination phase half life, using a 3-compartment model. ADVAN 12 and TRANS6 seems to be a way. However, I am using the intercompartment clearance and volumes based parameterization, e.g. Q3,V3 etc.. = log(2)/gamma

Could anyone please share NONMEM code to compute the half-life based on gamma?

Thanks so much in advance.

Best regards,

Paolo Denti, PhD
Pharmacometrics Group
Division of Clinical Pharmacology
Department of Medicine
University of Cape Town

K45 Old Main Building
Groote Schuur Hospital
Observatory, Cape Town
7925 South Africa
phone: +27 21 404 7719
fax: +27 21 448 1989
email: paolo.denti

Disclaimer - University of Cape Town This e-mail is subject to UCT policies and e-mail disclaimer published on our website at or obtainable from +27 21 650 9111. If this e-mail is not related to the business of UCT, it is sent by the sender in an individual capacity. Please report security incidents or abuse via csirt
Received on Wed Mar 30 2016 - 12:59:41 EDT

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to:

Once subscribed, you may contribute to the discussion by emailing: