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RE: [NMusers] Simultaneous pk model of 2 drugs

From: Pavel Belo <>
Date: Mon, 5 Sep 2016 21:03:38 -0400 (EDT)



Hello Chris,


What is the point of modeling 2 drugs in one NONMEM
code?  Do the drugs interact?  For example, you can have 2 monocl=
antibodies competing for or binding to the same target and/or
concentration of
one drug changes elimination rate or some other parameters of the other
one.  If they do not interact, you can
model them separately.  In some cases,
even if they interact you can model them separately using dose of one
drug as a
covariate for the other one.





On Fri, Sep 02, 2016 at 01:22 PM, Penland, Chris wrote:

Greetings NMusers,


Does nonmem have the capacity, unbeknownst to me, for modeling two
simultaneous drugs?


I would like some suggestions about how to define the dataset and model
for a subcutaneous drug and oral drug being administered on different
schedules. I would use DVID = 1 and 2 for the two plasma pk
observations.  I figure this soft
  of thing had to be dealt with in the past when trying to model dynamic
DDIs (vs, just taking one of the drugs as a covariate on the other’=


One approach is to specify the compartments for each to be dosed into
then have those feed the central, but I’m curious to see if there i=
something more subtle in the nonmem syntax. Is there something about
EVID, that I don’t know that
  would help (beyond EVID=1 for dosing)


What if you had two oral drugs? Would you treat the two dosing
compartments as separate and possibly link them together at the
parameter/covariance level?






Chris Penland, PhD

ECD / Quantitative Clinical Pharmacology

Waltham, MA USA


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Received on Mon Sep 05 2016 - 21:03:38 EDT

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