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[NMusers] Pharmacometrics & Systems Pharmacology Positions at Genentech, in South San Francisco, California

From: Angelica Quartino <quartino.angelica_at_gene.com>
Date: Fri, 24 Feb 2017 13:42:57 -0800

Dear NMusers,



Genentech is hiring at all experience levels (multiple opportunities
available) in South San Francisco, California


*Welcome to join our great team and be part of amazing science to help
patients.*



Please apply through the links below.


*Kind regards Angelica Quartino, Dan Lu and Jin Jin*


---------------------------------------------------------------------------------
Angelica Quartino, Ph.D.
*Modeling and Simulation (M&S) Group Leader OMNI*
*Sr. Scientist, Clinical Pharmacology, gRED*
*Genentech Inc*
*Address: Mail Stop 463A, **1 DNA Way, S**outh San **Francisco**, CA 94080*
*Office: 650- <650-467-2198>467-6662 Mobile: 415-528-0744
Email: quartino.angelica_at_gene.com <quartino.angelica_at_gene.com>*



*MODELING AND SIMULATION THERAPEUTIC AREA LEAD OR GROUP LEADER (Senior
Scientist/Principal Scientist)*


*http://jobs.gene.com/00451607 <http://jobs.gene.com/00451607>*

*The Position*

The Clinical Pharmacology Department at Genentech, Inc. is seeking a Ph.D.
level Senior Scientist or Principal Scientist who is driven to use
pharmacometrics and system pharmacology approaches to advance the clinical
development of novel drug candidates. As a strategic and scientific leader,
this individual could act as Modeling and Simulation (M&S) Therapeutic Area
Lead (TAL) or Group Leader (GL) depending on qualification. As the M&S TAL
or GL, the individual will be responsible to oversee the strategy and
implementation of the platform and project M&S in one or more therapeutic
areas (such as Cancer Immunotherapy), and involve Clinical Pharmacology TAL
or GL as needed for their respective TAs. The M&S activities include
population PK/PD models, translational models, PBPK, systems pharmacology
models, disease models, clinical trial simulations, literature
meta-analysis, and other state of the art modeling and simulation
techniques. Other key responsibilities are to establish close relationship
with cross-functional key stakeholders (eg. functional leaderships, TA
leads, and governance committee reviewers etc.), to serve as reviewer for
relevant clinical or regulatory documents (eg. M&S reports, IND, End-of
Phase 2 meeting, EU Scientific Advice meeting, BLA, NDA, sNDA, sBLA, etc.)
and at relevant review forums (PKRF/OBRF/DxRF/DSRG/DRC), and as a member of
the M&S Leadership Team (MSLT) or the Clinical Pharmacology Leadership Team
(CPLT) as relevant with organizational responsibilities. These will be
accomplished by working in close partnership with other scientists in
Clinical Pharmacology, Clinical Science, Biostatistics, Preclinical and
Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics,
Regulatory, and other functions on project teams. As M&S TAL or GL, the
individual will contribute to planning and managing M&S resources and
forecasting for the corresponding TAs. Qualified candidate will also be
responsible to manage a group of scientists via direct and/or matrix
management system.

*Who You Are*

EDUCATION:

A Ph.D. in Pharmacometrics, Pharmaceutical Sciences, Biomedical or Chemical
Engineering, Biostatistics, Applied Mathematics or Physics, or related
discipline 7+ years (for Senior Scientist) or 15+ years (for Principal
Scientist) of industry, regulatory, and/or related post-doctoral Modeling
and Simulation experience is required.

REQUIREMENTS:

Candidates should have solid expertise in quantitative pharmacology, strong
hands-on modeling and simulation skills, and demonstrated impact on drug
development through quantitative approaches. Rich hands-on experience with
NONMEM, SPLUS, R, Simcyp, GastroPlus, SimBiology, and/or other modeling and
simulation software is required. Working experience with mechanistic PK/PD
and/or system pharmacology modeling will be highly preferred. The candidate
must have excellent communication and interpersonal skills and the ability
to work independently and effectively on interdepartmental project teams.
People management experience is highly desired. Experience in interaction
with global regulatory agencies is a plus. The candidate must have strong
leadership skills and the ability to influence. Candidate for the M&S Group
Leader role must have proven track record of strong strategic leadership
and people management skills in a fast-paced multi-tasked matrix
environment.


*PHARMACOMETRICS AND SYSTEMS PHARMACOLOGY MODELER (Associate
Scientist/Scientist/Senior Scientist)*


*http://jobs.gene.com/00451478 <http://jobs.gene.com/00451478>*

*The Position*

The Clinical Pharmacology Department at Genentech, Inc. is seeking Ph.D.
level Associate Scientist, Scientist, or Senior Scientist who is driven to
use quantitative approaches to advance the clinical development of novel
drug candidates. This individual will be responsible for the development
and implementation of the platform and project Modeling and Simulation
(M&S) strategy, in order to ensure that the right drug is administered to
the right patient at the right dose and regimen. The modeling and
simulation activities include population PK/PD models, translational
models, PBPK, systems pharmacology models, disease models, clinical trial
simulations, literature meta-analysis, and other state of the art
quantitative techniques. Candidate specialized in quantitative systems
pharmacology (QSP) M&S will be responsible for the development and
integration of a variety of mechanistic modeling of biological systems,
including models of intracellular signaling pathways, cell networks
dynamics, disease models, and mechanistic PK/PD models, in the context of
specific molecule or therapeutic area needs to support clinical trials such
as dosing, patient selection, biomarker and diagnostic investigation,
combination therapy identification and optimization.

Key technical responsibilities are to organize, execute, and report
Pharmacometrics and/or Systems Pharmacology M&S independently, as well as
to present work at cross-functional teams, department meetings, senior
management review committees, regulatory interactions, and scientific
conferences. Other responsibilities will include planning, writing, and
reviewing relevant clinical documents such as study protocols, analysis
plans, reports, and regulatory documents. These will be accomplished by
working in close partnership with other scientists in Clinical
Pharmacology, Clinical Science, Biostatistics, Preclinical and
Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics,
Regulatory, and other functions on project teams. Qualified individual
could be responsible for overseeing the strategy and implementation of
Pharmacometrics and Systems Pharmacology M&S by other scientists across
projects.

*Who You Are*

EDUCATION:

A Ph.D. in Pharmacometrics, Biomedical or Chemical Engineering,
Biostatistics, Applied Mathematics or Physics, Pharmaceutical Sciences, or
related discipline with 0+ year (for Associate Scientist), 3+ years (for
Scientist), 7+ years (for Senior Scientist) of industry, regulatory, and/or
related post-doctoral Modeling and Simulation experience is required.

REQUIREMENTS:

Candidates should have solid expertise in quantitative pharmacology and
strong hands-on modeling and simulation skills. Demonstrated impact on drug
development through quantitative approaches is highly desired. Rich
hands-on experience with NONMEM, SPLUS, R, Simcyp, GastroPlus, SimBiology,
and/or other modeling and simulation software is required. Experience with
clinical trial simulation, optimal design, advanced mechanistic PK/PD
and/or system pharmacology modeling is highly preferred. Experience in
interaction with regulatory agencies is highly desired. The candidate must
have excellent communication and interpersonal skills and the ability to
work independently and effectively on interdepartmental project teams. The
candidate must have strong leadership skills and the ability to influence.
People management experiences are a plus.

Received on Fri Feb 24 2017 - 16:42:57 EST

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