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[NMusers] Job Posting: Research Scientist-PBPK Modeler

From: Gemma Louise Dickinson <dickinson_gemma_louise_at_lilly.com>
Date: Mon, 31 Jul 2017 18:22:30 +0000

Research Scientist-PBPK Modeler (To apply: http://bit.ly/32999_GD)



At Lilly, we unite caring with discovery to make life better for people aro=
und the world. We are a global healthcare leader headquartered in Indianapo=
lis, Indiana. Our 39,000 employees around the world work to discover and br=
ing life-changing medicines to those who need them, improve the understandi=
ng and management of disease, and give back to our communities through phil=
anthropy and volunteerism. We give our best effort to our work, and we put =
people first. We're looking for people who are determined to make life bett=
er for people around the world.



The Mechanistic Pharmacokinetics group within The Department of Drug Dispos=
ition (ADME) is searching for a PBPK modeler. The Department of Drug Dispos=
ition is a multidisciplinary group, utilizing in vitro, in vivo, and in sil=
ico approaches to study the pharmacokinetics, absorption, and disposition o=
f new chemical entities. The scientist will function as a PBPK modeler, par=
t of a team responsible for providing innovative mechanistic PK models to d=
rive and influence decision making on drug Discovery and Development projec=
t teams.



Some of the key responsibilities may include:

* Evaluate and apply innovative PBPK/MPK approaches to translate and predic=
t human PK.

* Use modeling as a tool to help generate hypotheses, design better studies=
, inform clinical plans and support registration.

* Peer review modeling work from colleagues as appropriate, ensuring high q=
uality standards.

* Provide expert modeling consultancy, training and support to others withi=
n ADME and within the larger R&D organization

* Liaise with ADME, PK/PD and Clinical Pharmacology representatives to comm=
unicate the assumptions, limitations, meaning and impact of mechanistic PK =
models.

* Promote and increase the reputation of mechanistic modeling approaches bo=
th internally within R&D and externally including regulatory agencies

* Provide training and coaching to scientists within the department to incr=
ease mechanistic thinking and the application and impact of mechanistic mod=
elling.

* Build a strong external network in the field of mechanistic modeling (e.g=
. academia, consortia) and keep up to date with emerging literature and sci=
ence in the area



Basic Qualifications

* Ph.D. in PBPK modeling, Pharmacokinetics or a related field or MS and 7 y=
ears or BS and 10 years or of applicable experience in PBPK, Pharmacokineti=
cs modeling or related field



Additional Skills/Preferences

* Hands-on experience in modeling software like SimCYP, GastroPlus, MatLab/=
Simbiology, NONMEM etc. is required.

* Must have a thorough understanding of pharmacokinetics, ADME and PBPK mod=
eling and ability to communicate theory and concepts clearly

* Understanding of the implications of PBPK modeling and drug-drug interact=
ion simulations for drug labelling and the international regulatory guidanc=
e pertaining to those activities

* Collaborative behaviors to build and maintain relationships with R&D cust=
omers and the wider modeling community.

* Ability to influence, negotiate and communicate with both internal and ex=
ternal stake holders



Limited travel required for conferences, external reviews, and regulatory m=
eetings.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on th=
e basis of age, race, color, religion, gender, sexual orientation, gender i=
dentity, gender expression, national origin, protected veteran status, disa=
bility or any other legally protected status.


Gemma L. Dickinson
Director, Drug Disposition
Eli Lilly and Company
Lilly Corporate Center, Indianapolis IN 46285 U.S.A.
+1 317.209.5500 (mobile)
dickinson_gemma_louise_at_lilly.com<mailto:emailaddress_at_lilly.com> | www.lilly=
.com<http://www.lilly.com/>
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CONFIDENTIALITY NOTICE: This email message (including all attachments) is f=
or the sole use of the intended recipient(s) and may contain confidential i=
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on is strictly prohibited. If you are not the intended recipient, please co=
ntact the sender by reply email and destroy all copies of the original mess=
age.






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Received on Mon Jul 31 2017 - 14:22:30 EDT

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