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Opportunities in Pharmacometrics at Pfizer

From: Nicholas, Timothy <Timothy.Nicholas>
Date: Mon, 9 Oct 2017 19:25:46 +0000

This is an exciting time to be at Pfizer.

Our Pharmacometricians have an important role in influencing the discovery =
and development of drugs. It's fascinating, vital work and you could be pa=
rt of it.

Pharmacometricians at US locations

In this key role as a member of our Global Pharmacometrics group within the=
 Clinical Pharmacology Department, you will be responsible for providing ex=
pert study/program design, data analytical and interpretation inputs to our=
 various Research, Development and Business Unit organizations. The success=
ful candidates will work as partners of disease area aligned multi-discipli=
nary teams in providing model informed drug discovery and development exper=
tise and leadership to a variety of through to loss of patent exclusivity. =
Of key importance will be the formation and maintenance of effective collab=
orations with amongst others, statistical, clinical and clinical pharmacolo=
gy members of these teams.

Pharmacometricians provide strategic input into pre-clinical discovery, dev=
elopment and post-approval plans quantifying the risk associated with parti=
cular study designs or program strategies and communicating/dissemination o=
f the results. They are responsible for the use of a variety of innovative =
quantitative methods to integrate knowledge of pharmacokinetics, a variety =
of response variables (including pharmacodynamic, clinical outcome and unde=
sirable effects), patient characteristics and disease mechanism/states, sta=
tistics, study/experimental design, clinical trial simulations, meta-analyt=
ical evidence synthesis and quantitative techniques to facilitate quantitat=
ive decision making thereby increasing drug research and development effici=

In addition to the disease specific project activities the successful candi=
dates will forge collaborative relationships with Pharmacometric colleagues=
 within the Global Pharmacometrics community (currently based in USA, UK, C=
hina and Japan), other subject matter specialists and groups external to th=
e organization (leading academics, external service providers etc.). The su=
ccessful candidates will work with colleagues to ensure Pfizer's position a=
s a leader in the use of quantitative approaches supporting drug research a=
nd development strategies and worldwide registration of new medicines.

Pharmacometricians routinely interact with internal governance bodies, regu=
latory agencies and external opinions leaders. They are expected to influe=
nce the external environment by advancing their discipline and through exte=
rnal presentations and publications.

The ideal candidates will have a doctorate degree with demonstrated experti=
se in Pharmacometrics and strong quantitative skills (e.g. experience in me=
chanistic modelling/systems pharmacology, quantitative translational scalin=
g, literature meta-analyses, population PK and PK-PD modelling, and clinica=
l trial simulations). We encourage applicants from different disciplines in=
cluding pharmaceutical sciences, biostatistics, medicine, engineering, etc.=
  Candidates with significant experience are sought as well as recent gradu=
ates. In addition to professional challenge, we offer a culture that suppor=
ts and encourages ideas, and recognizes individual contribution. Moreover, =
the salary and extensive benefits are everything you'd expect from a world =
leading company

To apply please visit the careers pages on<http://www=> and enter the relevant job opening number:

If you are early in your career please consider a Pharmacometrics Manager p=
osition, and look for job opening number: 1610568 and 1614913. If you have =
an established track record of drug research and development impact please =
consider a Pharmacometrics Director position, and look for job opening numb=
er: 1045468.

Timothy Nicholas, PhD
Global Clinical Pharmacology


Received on Mon Oct 09 2017 - 15:25:46 EDT

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