Combining mechanistic modeling with machine learning to predict cardiotoxic=
ity and streamline drug development
Eric Sobie, PhD
Professor, Pharmacological Sciences
Icahn School of Medicine at Mount Sinai, New York, NY
Wednesday, December 12, 2018, 12:00 to 1:00 pm EST
Register at
https://www.rosaandco.com/webinars/2018/combining-mechanistic-m=
odeling-machine-learning
Abstract:
Quantitative Systems Pharmacology (QSP) uses simulations with mechanistic m=
athematical models to improve drug development. Dr. Sobie will discuss rece=
nt and ongoing studies to exploit the power of QSP to improve understanding=
and prediction of cardiotoxicity. Specifically, Dr. Sobie will describe ho=
w simulations with mechanistic QSP models can be combined with machine lear=
ning algorithms to address unresolved questions.
This integration of statistical and dynamical modeling provides a powerful =
approach for prioritizing experimental studies, overcoming limitations of e=
xperimental models, and identifying patient subgroups most at risk of devel=
oping cardiotoxicity.
Received on Tue Dec 04 2018 - 13:59:31 EST
