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Job position in Clinical Pharmacology Modelling & Simulation at GlaxoSmithKline in Shanghai

From: Peiming Ma <>
Date: Fri, 9 Feb 2018 12:26:42 +0000

Dear all,

We wish to announce a senior-level position (Sr. Scientist to Director) in =
the Clinical Pharmacology Modelling and Simulation (CPMS) group of GlaxoSmi=
thKline (GSK) in Shanghai.

GSK provides a supportive environment for scientists who are aspired to lea=
rn, to contribute and to make impact on business decisions through innovati=
on. The position level for a successful candidate will be based on the pers=
on's skills and experience. As a member of our global CPMS department, you =
have the opportunities to work as the clinical pharmacology lead for China =
and global development/registration projects.

Below are the responsibilities and qualifications for the position. If inte=
rested, please send your CV to:<>.

Peiming Ma

Responsibilities may include:

  * Contribute, as a member of a multi-discipline team, to the design of =
an efficient clinical development program and a robust registration package
  * Play a central role in predicting human dose range, characterizing do=
se-response relationship and justifying dose recommendations for special po=
  * Develop mathematical and statistical models to understand a disease, =
its progression, and pharmacodynamics and pharmacokinetics; conduct meta-an=
alyses as appropriate to maximize data use; conduct simulations to assess t=
rial design performance
  * Design and interpret clinical pharmacology studies, including those t=
o evaluate potential effects of intrinsic and extrinsic factors on pharmaco=
kinetics and pharmacodynamics
  * Write sections of drug development and registration documents such as=
 clinical trial protocols and reports, clinical investigator brochures and =
regulatory submission packages
  * Present and defend quantitative clinical pharmacology plans and resul=
ts through interaction and negotiation with internal governance committees =
and external regulators
  * Innovate through working effectively with colleagues in the departmen=
t and others such as statisticians, biologists, physicians and drug metabol=
ism scientists
  * Learn and apply emerging modelling and simulation methodologies with =
a view to enhance clinical program efficiency and investment decision quali=
ty; collaborate with external field-leading teams for methodology applicati=
  * Promote model-informed drug development approach by publishing in pee=
r-reviewed journals and presenting at scientific conferences

Basic and preferred qualifications are:

  * Advanced training with a degree such as PhD, PharmD and MD to enable =
a successful career in quantitative clinical pharmacology in pharmaceutical=
 research and development
  * Knowledge of, or ability to quickly learn, the mechanism, endpoints, =
progression and treatments of relevant diseases
  * Understanding of pharmacokinetic and pharmacodynamic principles and c=
ommonly applied models; working knowledge of common tools for quantitative =
clinical pharmacology such as NONMEM, R, WINNONLIN, Simcyp, SAS and MATLAB
  * Experience in designing, analyzing and reporting clinical studies, wi=
th a simulation- or modelling-based approach where appropriate
  * Familiarity with regulatory submission documents such as CTAs, INDs, =
NDAs, MAAs and BLAs
  * Ability to communicate clearly and succinctly with the audience in mi=
nd, both orally and in writing
  * Ability to build effective collaboration while taking personal accoun=
tability for delivery of quantitative clinical pharmacology results
  * Sound judgement, analytical mindset and problem-solving skills
  * Ability to effectively multi-task and deliver results on time

GSK monitors email communications sent to and from GSK in order to protect =
GSK, our employees, customers, suppliers and business partners, from cyber =
threats and loss of GSK Information. GSK monitoring is conducted with appro=
priate confidentiality controls and in accordance with local laws and after=
 appropriate consultation.

Received on Fri Feb 09 2018 - 07:26:42 EST

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