NONMEM Users Network Archive

Hosted by Cognigen

[NMusers] Problem with fpi in NONMEM 7.3

From: Pieter Colin <Pieter.Colin_at_UGent.be>
Date: Thu, 4 Jan 2018 10:08:44 +0000

Dear NM users,

I've been encountering a problem when using NONMEM 7.3 and the file passing=
 interface for parallel computing.
The run I'm trying to get going consists of 5 problems within a single NONM=
EM run.
Here is a short extract of the script:

$PROBLEM Fit cohort 1
$INPUT ...
$DATA data.csv IGNORE=_at_ IGNORE(COHORT.EQ.1) REWIND
...
$ESTIMATION ... MSFO=run1.msf
---
$PROBLEM Post hoc predictions
$INPUT ...
$DATA data.csv IGNORE=_at_ IGNORE(COHORT.NE.1) REWIND
$MSFI run1.msf
...
$ESTIMATION ... MAX=0
---
$PROBLEM Fit cohort 2
$INPUT ...
$DATA data.csv IGNORE=_at_ IGNORE(COHORT.EQ.2) REWIND
...
$ESTIMATION ... MSFO=run1.msf
---
$PROBLEM Post hoc predictions
$INPUT ...
$DATA data.csv IGNORE=_at_ IGNORE(COHORT.NE.2) REWIND
$MSFI run1.msf
...
$ESTIMATION ... MAX=0
---
$PROBLEM Fit all data
$INPUT ...
$DATA data.csv IGNORE=_at_ REWIND
...
$ESTIMATION ...

The script works perfectly fine without the parallel computing option. When=
 using the fpi I get the following error message:

At line 169 of file <unit = 26, file = ´FILE26´>
Fortran runtime error: End of File

The run consistently fails when initiating problem 5 (i.e. the initial OFV =
evaluation).
I've searched the NONMEM guides, and tried looking for some information onl=
ine on gfortran but I was not able to identify the problem.
Hopefully someone on this forum can shed some light on this behavior.

Warm regards,

Pieter Colin
Department of Anesthesiology
University Medical Center Groningen


Received on Thu Jan 04 2018 - 05:08:44 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request_at_iconplc.com. Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.