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RE: [NMusers] $ABBR REPLACE Limitations?

From: Bauer, Robert <Robert.Bauer_at_iconplc.com>
Date: Wed, 24 Jan 2018 17:35:18 +0000

Bill:
The straight substitutions should work for any variable. Alison and I discovered a minor glitch in nm74 (it works okay in nm73), where substitution does not occur if there is a space between the name and the = sign in the execution statement. So, instead of

FCMTD1GUT = THETA(1)

try

FCMTD1GUT= THETA(1)

and see if that works.

Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer_at_iconplc.com<mailto:Robert.Bauer_at_iconplc.com>
www.iconplc.com<http://www.iconplc.com/>

From: William Denney [mailto:wdenney_at_humanpredictions.com]
Sent: Wednesday, January 24, 2018 4:08 AM
To: Bauer, Robert
Cc: Luann Phillips; nmusers
Subject: Re: [NMusers] $ABBR REPLACE Limitations?

Hi Bob,

Thanks for this confirmation. I'm using 7.4.1.

For my other question, is there a limitation of $ABBR REPLACE which prevents its use for parameters like F1 and ALAG1?

Thanks,

Bill

On Jan 24, 2018, at 00:43, Bauer, Robert <Robert.Bauer_at_iconplc.com<mailto:Robert.Bauer_at_iconplc.com>> wrote:
This bug has been fixed since NONMEM 7.4


Bug #1, nm730_bug_list.pdf in https://nonmem.iconplc.com/nonmem730<https://nonmem.iconplc.com/nonmem730>
Two variables with names longer than six characters, and identical in the first six characters, defined in $PK, and used in $DES, will be seen as the same variable. Use variable names that differ in the first six characters. This occurs in NONMEM 7.1.0, 7.1.2, 7.2.0, and 7.3.0. A workaround is to move all assignment statements for variables whose first 6 characters match to $DES.

Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer_at_iconplc.com<mailto:Robert.Bauer_at_iconplc.com>
www.iconplc.com<http://www.iconplc.com/>

From: owner-nmusers_at_globomaxnm.com<mailto:owner-nmusers_at_globomaxnm.com> [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of Bill Denney
Sent: Tuesday, January 23, 2018 4:40 PM
To: Luann Phillips
Cc: nmusers
Subject: RE: [NMusers] $ABBR REPLACE Limitations?

Hi Luann,

I’m not having similar problems with other parameters with >6 characters. I had a similar issue with ALAG1, so I think that there are limitations on what types of variables you can remap. (Perhaps Allison or Bob could confirm?)

Thanks,

Bill

From: Luann Phillips [mailto:luann_at_cognigencorp.com<mailto:luann_at_cognigencorp.com>]
Sent: Tuesday, January 23, 2018 3:51 PM
To: Bill Denney <wdenney_at_humanpredictions.com<mailto:wdenney_at_humanpredictions.com>>
Cc: nmusers <nmusers_at_globomaxnm.com<mailto:nmusers_at_globomaxnm.com>>
Subject: Re: [NMusers] $ABBR REPLACE Limitations?

Bill,

I know at one time NM had a bug (haven't checked to see if it has been fixed) that would cause variables with the first 6 characters the same to be interpreted as the same variable even when later characters differed. I wonder if this is a similar issue?
Have you tried a shorter variable name, such as FCD1GUT=F1?

Just a thought,
Luann

________________________________
From: "Bill Denney" <wdenney_at_humanpredictions.com<mailto:wdenney_at_humanpredictions.com>>
To: "nmusers" <nmusers_at_globomaxnm.com<mailto:nmusers_at_globomaxnm.com>>
Sent: Tuesday, January 23, 2018 2:15:32 PM
Subject: [NMusers] $ABBR REPLACE Limitations?

Hi,

I’m working in NONMEM 7.4.1 with a model where I need to track 4 drugs simultaneously. To increase the model quality, I’m making heavy use of $ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an issue with my model where there was no gradient on a bioavailability term to the fact that this substitution didn’t seem to be working:

$ABBR REPLACE FCMTD1GUT=F1

$PK

FCMTD1GUT = THETA(1)

FCMTD1GUT didn’t seem to be effectively replaced to F1, so the bioavailability parameters had no effect. When I changed it to just directly name F1, it worked as expected.

$PK

F1 = THETA(1)

It’s not obvious from the $ABBR REPLACE section of the manual that this is a limitation of $ABBR REPLACE. Is this an issue or am I missing something?

Thanks,

Bill

________________________________
<image001.jpg><http://www.humanpredictions.com/>William S. Denney, PhD
Chief Scientist, Human Predictions LLC
+1-617-899-8123
wdenney_at_humanpredictions.com<mailto:wdenney_at_humanpredictions.com>
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Received on Wed Jan 24 2018 - 12:35:18 EST

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