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RE: [NMusers] $ABBR REPLACE Limitations?

From: Bill Denney <wdenney_at_humanpredictions.com>
Date: Wed, 24 Jan 2018 13:09:23 -0500

Hi Bob,



It looks like that was my issue.



Thanks,



Bill



*From:* Bauer, Robert [mailto:Robert.Bauer_at_iconplc.com]
*Sent:* Wednesday, January 24, 2018 12:35 PM
*To:* William Denney <wdenney_at_humanpredictions.com>
*Cc:* Luann Phillips <luann_at_cognigencorp.com>; nmusers <
nmusers_at_globomaxnm.com>
*Subject:* RE: [NMusers] $ABBR REPLACE Limitations?



Bill:

The straight substitutions should work for any variable. Alison and I
discovered a minor glitch in nm74 (it works okay in nm73), where
substitution does not occur if there is a space between the name and the =
=
sign in the execution statement. So, instead of



FCMTD1GUT = THETA(1)



try



FCMTD1GUT= THETA(1)



and see if that works.



Robert J. Bauer, Ph.D.

Senior Director

Pharmacometrics R&D

ICON Early Phase

820 W. Diamond Avenue

Suite 100

Gaithersburg, MD 20878

Office: (215) 616-6428

Mobile: (925) 286-0769

Robert.Bauer_at_iconplc.com

www.iconplc.com



*From:* William Denney [mailto:wdenney_at_humanpredictions.com
<wdenney_at_humanpredictions.com>]
*Sent:* Wednesday, January 24, 2018 4:08 AM
*To:* Bauer, Robert
*Cc:* Luann Phillips; nmusers
*Subject:* Re: [NMusers] $ABBR REPLACE Limitations?



Hi Bob,



Thanks for this confirmation. I'm using 7.4.1.



For my other question, is there a limitation of $ABBR REPLACE which
prevents its use for parameters like F1 and ALAG1?



Thanks,



Bill


On Jan 24, 2018, at 00:43, Bauer, Robert <Robert.Bauer_at_iconplc.com> wrote:

This bug has been fixed since NONMEM 7.4





Bug #1, nm730_bug_list.pdf in https://nonmem.iconplc.com/nonmem730

Two variables with names longer than six characters, and identical in the
first six characters, defined in $PK, and used in $DES, will be seen as the
same variable. Use variable names that differ in the first six
characters. This occurs in NONMEM 7.1.0, 7.1.2, 7.2.0, and 7.3.0. A
workaround is to move all assignment statements for variables whose first 6
characters match to $DES.



Robert J. Bauer, Ph.D.

Senior Director

Pharmacometrics R&D

ICON Early Phase

820 W. Diamond Avenue

Suite 100

Gaithersburg, MD 20878

Office: (215) 616-6428

Mobile: (925) 286-0769

Robert.Bauer_at_iconplc.com

www.iconplc.com



*From:* owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com
<owner-nmusers_at_globomaxnm.com>] *On Behalf Of *Bill Denney
*Sent:* Tuesday, January 23, 2018 4:40 PM
*To:* Luann Phillips
*Cc:* nmusers
*Subject:* RE: [NMusers] $ABBR REPLACE Limitations?



Hi Luann,



I’m not having similar problems with other parameters with >6 chara=
cters.
I had a similar issue with ALAG1, so I think that there are limitations on
what types of variables you can remap. (Perhaps Allison or Bob could
confirm?)



Thanks,



Bill



*From:* Luann Phillips [mailto:luann_at_cognigencorp.com]
*Sent:* Tuesday, January 23, 2018 3:51 PM
*To:* Bill Denney <wdenney_at_humanpredictions.com>
*Cc:* nmusers <nmusers_at_globomaxnm.com>
*Subject:* Re: [NMusers] $ABBR REPLACE Limitations?



Bill,



I know at one time NM had a bug (haven't checked to see if it has been
fixed) that would cause variables with the first 6 characters the same to
be interpreted as the same variable even when later characters differed. I
wonder if this is a similar issue?

Have you tried a shorter variable name, such as FCD1GUT=F1?



Just a thought,

Luann


------------------------------

*From: *"Bill Denney" <wdenney_at_humanpredictions.com>
*To: *"nmusers" <nmusers_at_globomaxnm.com>
*Sent: *Tuesday, January 23, 2018 2:15:32 PM
*Subject: *[NMusers] $ABBR REPLACE Limitations?



Hi,



I’m working in NONMEM 7.4.1 with a model where I need to track 4 dr=
ugs
simultaneously. To increase the model quality, I’m making heavy us=
e of
$ABBR REPLACE to keep track of THETA, ETA, and CMT numbers. I traced an
issue with my model where there was no gradient on a bioavailability term
to the fact that this substitution didn’t seem to be working:



$ABBR REPLACE FCMTD1GUT=F1



$PK



FCMTD1GUT = THETA(1)



FCMTD1GUT didn’t seem to be effectively replaced to F1, so the
bioavailability parameters had no effect. When I changed it to just
directly name F1, it worked as expected.



$PK



F1 = THETA(1)



It’s not obvious from the $ABBR REPLACE section of the manual that =
this is
a limitation of $ABBR REPLACE. Is this an issue or am I missing something?



Thanks,



Bill


------------------------------

<image001.jpg> <http://www.humanpredictions.com/>*William S. Denney, PhD*
Chief Scientist, Human Predictions LLC
+1-617-899-8123
wdenney_at_humanpredictions.com

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Received on Wed Jan 24 2018 - 13:09:23 EST

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