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Advanced course on Pharmacometrics

From: roberto gomeni <roberto.gomeni>
Date: Thu, 21 Jun 2018 11:10:08 +0200

PharmacoMetrica is holding the:


10th Advanced course on Pharmacometrics

November 5-8, 2018: Chateau de Longcol (France)


This is a 3-day course designed to present advanced concepts on
pharmacometrics using novel methodologies based on integrated
drug-disease-trial models and surface response analysis. Case studies are
presented to illustrate how these tools can be used for improving the
decision-making process during drug development, for facilitating the
development and use of predictive models for describing complex PK profiles,
in-vitro/in-vivo correlation, and exposure-response relationships in
presence of confounding factors such as placebo effect and tolerance.

Course objectives


To present concepts and practical solutions for:

Advanced PK modeling

* To characterize the complex in-vivo absorption processes of
extended release formulations (ER) and Long Acting Injectable (LAI)
formulations using convolution-based approach

* To evaluate In-Vitro/In-Vivo correlation methods, including
convolution-deconvolution approach


Advanced exposure-response modeling

* To evaluate the relationship between drug exposure and clinical

* To develop models accounting for the confounding role of time
varying placebo response in the assessment of the clinical response

* To develop integrated disease-drug-trial models

* To handle acute tolerance effect

* To estimate the probability of clinical benefit of a treatment


Optimizing drug performances

* To implement drug optimization strategies using surface-response

* To determine the relationship between drug delivery and clinical

* To determine dose, dosage regimen and dosing strategies for
optimizing the clinical benefit


Course material


The R scripts (including Shiny based applications) used in the hands-on
sessions and the NONMEM control streams will be distributed to the
participants. The material includes:


o the convolution/deconvolution analysis,

o the clinical trial simulator for describing the clinical response in
presence of placebo and active drug response,

o the estimation of the optimal in-vitro dissolution profiles

o the convolution/deconvolution analysis,

o the non-linear optimizer used in the surface-response analysis




Venue: Chateau de Longcol (France): <>


Additional details are available at:


Received on Thu Jun 21 2018 - 05:10:08 EDT

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