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[NMusers] Opening Position at Sanofi - Paris - France

From: <Laurent.Nguyen_at_sanofi.com>
Date: Tue, 13 Mar 2018 15:42:45 +0000

Open full time position at Sanofi R&D - Location: Paris (France)
Job Title: Modeling Scientist
Sanofi R&D is looking for a highly motivated and creative individual to joi=
n its Modelling & Simulation group in Paris. The individual will primarily =
be responsible for developing and executing PK/PD and Physiologically-based=
 PK (PBPK) Modelling and Simulations (M&S) analyses to support drug develop=
ment from discovery to late clinical stages in a variety of therapeutic are=
as (Oncology, Immuno-Inflammation, Central Nervous System, Cardiovascular, =
Infectious disease) for both small and large molecules.
The candidate must have strong experience in PK/PD, PBPK modelling in the p=
harmaceutical industry and/or academia.

Main Responsibilities & Accountabilities:
  * Implements innovative quantitative methods to integrate data of pharmac=
okinetics, pharmacodynamics, biomarkers and preclinical or clinical outcome=
s with information of patient characteristics, pathway biology, disease phy=
siology and disease progression to facilitate quantitative decision making =
in support to projects.
  * Elaborates and executes PBPK and PK/PD modeling strategies in order to =
support model informed drug decisions in discovery programs, in strong coll=
aboration with preclinical teams (Biopharmacy, DMPK, pharmacology and toxic=
ology)
  * Works and communicates interactively with people from diverse scientifi=
c backgrounds in a multi-disciplinary environment and interacts effectively=
 with project teams representatives
  * Ensures quality of the study plan, protocols, reports, sections of repo=
rts required for regulatory submissions to health authorities
  * Maintains state-of-the art knowledge of modelling techniques and works =
in compliance with guidance of regulatory authorities.
Education and Experiences Required:
* PhD or equivalent degree in pharmaceutical sciences, mathematics or simil=
ar disciplines with demonstrated expertise and a track record in PBPK and P=
harmacometrics.
*Excellent programming skills (e.g.: R, Matlab, SAS,...) and solid hands-on=
 experience (minimum of 3 years' experience) in Population PK/PD modelling =
tools (e.g. NONMEM, Monolix, PFIM, STAN,..).
Also practice in Physiologically-based pharmacokinetics modelling (e.g.: Si=
mCYP, PK-sim MoBi, Gastro-Plus) would be a strong asset.
* Excellent written and verbal communication skills, with successful presen=
tation capabilities
* At ease in working in a dynamic matrix organization and team player
*Proficient in spoken and written English and ability to communicate in Fre=
nch is an asset but not mandatory
To apply or for further details on this position, please contact Laurent Ng=
uyen by email: laurent.nguyen_at_sanofi.com





Received on Tue Mar 13 2018 - 11:42:45 EDT

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