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RE: [NMusers] current sigma

From: Bauer, Robert <>
Date: Wed, 7 Nov 2018 20:10:06 +0000

Try the following examples, according to your need, in $PRED or $PK:



Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769

-----Original Message-----
From: [] On=
 Behalf Of
Sent: Sunday, November 04, 2018 7:03 PM
Subject: [NMusers] current sigma


I would like to know how to know current sigma values in a customized PRED
routine. In noncom.for file, it is documented that initial and final theta,
omega and sigma values are set in ROCM6, and current omega values are set i=
ROCM22. However, I cannot find current sigma values.

We developed a new program which can restore numerous time-course data by
expanding the analysis of nonlinear mixed effect model. Detail of our
analysis, named SReFT, is described in recent Clin Pharm Ther
(PMID:29951994). Currently, SReFT is implemented in my own program, Napp,
but I am considering its implementation in NONMEM. For the implementation o=
SReFT, it is necessary to know current sigma value in the PRED routine.

Akihiro Hisaka,
Chiba University, Japan.
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Received on Wed Nov 07 2018 - 15:10:06 EST

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