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[NMusers] Post-Doctoral Fellowship in Artificial Intelligence in Clinical Pharmacology at Astellas

From: Bonate, Peter <>
Date: Thu, 4 Apr 2019 16:38:47 +0000

Post-Doctoral Fellowship in Artificial Intelligence in Clinical Pharmacolog=
y at Astellas
The Pharmacometrics group in the Clinical Pharmacology and Exploratory Deve=
lopment (CPED) Department at Astellas has an immediate opening for a full-t=
ime, 1-year (with optional 2nd year) post-doctoral fellow in the applicatio=
n of Artificial Intelligence (AI) in Clinical Pharmacology. This highly mo=
tivated, intellectually curious scientist will work in a team environment t=
o explore how AI techniques, such as machine learning and deep learning, ca=
n be used to augment decision-making using traditional pharmacometric metho=
ds. In this role, you will have the opportunity to learn the drug developme=
nt process, how modeling and simulation is used to improve decision-making,=
 and work in a highly stimulating and engaging environment with other drug =
development scientists to help improve the lives of patients.
Astellas is a top 20 global pharmaceutical company located in Northbrook, I=
L, outside Chicago, and headquartered in Tokyo, Japan. Our therapeutic are=
as include oncology, immunology, muscle diseases, and regenerative medicine=
. Our therapeutic modalities include small molecules, large molecules (mon=
oclonal antibodies and derivatives), stem cells, gene therapy, oncolytic vi=
rus, adjuvant vector cells, and vaccines. Everyone at Astellas has a respon=
sibility for CHANGING TOMORROW(tm), for creating a brighter future for pati=
ents around the world. From the first moment, Astellas will inspire you to =
put this ethos into practice - with a positive, agile company culture and w=
ith well-defined ethical principles and values and systems.

Major Responsibilities:
* Develop an independent research project related to using AI techniq=
ues to enhance model-informed drug development. Projects may include, but a=
re not limited to, analysis of next-generation sequencing data, determinati=
on of stable dose requirements for new chemical entities, or use of structu=
red machine learning of integrated CDISC datasets for classification of res=
ponders and non-responders from clinical studies.
* Interact with core teams and extended teams, as well as at departme=
nt meetings, leadership team meetings, and regulatory meetings. This will i=
nclude presentation of proposals and results.
* Work closely with members of the Clinical Pharmacology and Explorat=
ory Development group, which includes clinical pharmacology scientists, tra=
nslational scientists, biomarker scientists, and pharmacometricians. Will a=
lso interact with other functions involved with AI, including commercial, A=
dvanced Analytics and Informatics, and statistics.
* Grow into an industry leader in the application of AI to clinical p=
harmacology and drug development
Competencies and Qualifications:
* Excellent written and oral skills; be able to explain results to te=
ams with diverse backgrounds and to management teams
* PhD in computer science, mathematics, engineering, physics, pharmac=
ometrics, or similar field, with demonstrated experience in artificial inte=
* Writing and reading experience with a programming language having s=
upporting AI packages, like Python, R, or Matlab.
* Demonstrated ability to work independently
* Experience with Microsoft Office Products, i.e., Word, Excel, Power=
Point, etc.
* Experience in working in a team environment is a plus
* Knowledge of the drug development process is a plus
* Understanding of traditional PKPD modeling and simulation methodolo=
gy a plus
* This is a full-time position located in Northbrook IL that may occa=
sionally require working nights or weekends and will have travel to meeting=
s or conferences.
* American citizenship required
If you are interested in applying, please contact Peter Bonate (peter.bonat=<>).

Astellas is an equal employment opportunity employer. All qualified applica=
nts will receive consideration for employment and will not be discriminated=
 against on the basis of race, color, sex, sexual orientation, gender ident=
ity, religion, disability, age, genetic information, veteran status, ancest=
ry, or national or ethnic origin.

Peter Bonate, PhD
Executive Director
Pharmacokinetics, Modeling, and Simulation
1 Astellas Way, N2.184
Northbrook, IL 60062<>
(224) 205-5855

I don't engage in gossip at work... but I can tell you who does. - a tweet

Received on Thu Apr 04 2019 - 12:38:47 EDT

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