NONMEM Users Network Archive

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[NMusers] PBPK modeling opening

From: Brenda Roseberry <broseberry_at_cartermackay.com>
Date: Thu, 4 Apr 2019 20:43:43 +0000

Scientist/Sr. Scientist opening in the US. Ideal location is in southern CA=
, but remote will also be considered. Please email me at broseberry_at_carterm=
ackay.com<mailto:broseberry_at_cartermackay.com> for more info


  * Analyze and interpret preclinical and clinical data. Study the effect=
 of diseases on animal and/or human physiology. Conduct research to further=
 understand the effects of healthy and disease states on drug absorption, d=
istribution, and elimination.
  * Use mechanistic, physiologically-based pharmacokinetic (PBPK) modelin=
g and simulation approaches to integrate knowledge of pharmacokinetics, pha=
rmacodynamics, efficacy, safety, patient demographics, and pathophysiologic=
al factors.
  * Perform mechanistic absorption/PBPK modeling and simulation to addres=
s objectives with client projects, including, but not limited to, FIH predi=
ctions, formulation design/optimization, population simulations, and DDI pr=
edictions.
  * Construct and validate mechanistic mathematical models for descriptio=
n of compound distribution in different tissues/organs in the body.
  * Write study proposals, study reports, and/or white papers to clearly =
describe model development and validation.
  * Discuss software applications with clients and prospects on telephone=
 or in person.
  * Share research findings by writing scientific articles and/or present=
ing at scientific conferences.
Requirements:

  * Ph.D. or Master's degree (or equivalent) in Pharmaceutical Science, B=
iostatistics, Biomedical Engineering, or related fields.
  * Minimum of three (3) years' experience as Scientist, Research Associa=
te, or related. (will consider at a higher level if someone is qualified)
  * Experience should include performing PBPK modeling of distribution of=
 compounds in animals and humans. It should also include performing PBPK/PD=
 analyses of clinical data, including drug absorption, drug-drug interactio=
n, metabolic stability, clearance, and protein binding.
  * Excellent oral and written communication skills.
  * Demonstrates and communicates a positive attitude while interacting w=
ith colleagues and clients at all levels.
  * Must be able to multitask and have strong organizational skills.
  * Self-motivated with ability to work with minimal supervision.
Job Location: southern CA or remote



[cid:1.1213385771_at_web31815.mail.mud.yahoo.com]
Brenda Roseberry
   Division Manager-Scientific
   Preclinical/Clinical--PK, Pharmacology, Pharmacometrics, Biomarkers
    720-328-9526 - Office
    315-415-4353 - Mobile
    720-475-1176 - Fax
   [cid:image001.png_at_01CBC1F8.25033B10] <http://www.linkedin.com/profile/vi=
ew?id=19937880&authType=name&authToken=b5d_>





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Received on Thu Apr 04 2019 - 16:43:43 EDT

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