NONMEM Users Network Archive

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Block SIZE with SCM

From: Emeric Sibieude <emeric.sibieude>
Date: Thu, 5 Dec 2019 07:39:55 +0000

Dear NMUsers,
I am performing scm with PsN. My data have more than 50 covariates, this s=
hould be processed by $SIZES PD=100 at the beginning of the NONMEM file.
However, it seems that scm command modifies this file by putting the block =
$PROBLEM at the first line.

Here is the beginning of my code :
$SIZES LVR=150 PD=-100
SPROBLEM empty model
$DATA ID TIME AMT EVID DV CAT1 CAT2 ...

Here is the code transformed in the LST file
$SIZES LVR=150 PD=-100 $PROBLEM empty model
$DATA ID TIME AMT EVID DV CAT1 CAT2 ...

And at the end I have the following error

NM-TRAN MESSAGES

AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.

AN ERROR WAS FOUND ON LINE 1 AT THE APPROXIMATE POSITION NOTED:
$SIZES LVR=150 PD=-100 $PROBLEM empty mod
                             X
THE CHARACTERS IN ERROR ARE: $
20 UNKNOWN OPTION.

Note that this is an issue for estimating the base model only. During the f=
orward path scm automatically drops the unnecessary covariates keeping only=
 the ones added at previous steps and the tested one. First estimate the ba=
se model and use the option -base_ofv seems to work however I will have the=
 same issue if more than 50 covariates are added during the forward path.
Thank you in advance for any help or any suggestions.
Best Regards,
Emeric Sibieude
Student trainee in Master's degree
Biopharma | R&D | Global Development | Translational Medicine
Merck
Lausanne , Switzerland
emeric.sibieude





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Received on Thu Dec 05 2019 - 02:39:55 EST

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