NONMEM Users Network Archive

Hosted by Cognigen

RE: [NMusers] Different OBJ after covariance with parallel and IMPMAP

From: Bauer, Robert <Robert.Bauer_at_iconplc.com>
Date: Sat, 9 Feb 2019 04:20:39 +0000

Mark:
As mentioned back in August, the failure occurs because your TIMEOUT parameter in the pnm file was not long enough, and a time out occurred, and NONMEM is not properly recovering from this. Therefore, the SEE’s should not be believed, as the subjects from the timed out processes would not be included.

Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer_at_iconplc.com<mailto:Robert.Bauer_at_iconplc.com>
www.iconplc.com<http://www.iconplc.com/>

From: Robert Bauer [mailto:bobjbauer_at_att.net]
Sent: Friday, February 08, 2019 8:08 PM
To: Bauer, Robert
Subject: Fw: [NMusers] Different OBJ after covariance with parallel and IMPMAP



----- Forwarded Message -----
From: Mark Sale <msale_at_nuventra.com>
Cc: nmusers_at_globomaxnm.com <nmusers_at_globomaxnm.com>
Sent: ‎Monday‎, ‎February‎ ‎4‎, ‎2019‎ ‎10‎:‎50‎:‎28‎ ‎AM‎ ‎PST
Subject: [NMusers] Different OBJ after covariance with parallel and IMPMAP


I've notices several times that when

using IMPMAP

and

Running parallel



the "one more iteration for variance" will fail on one (or more) of the processes. When it does this, the OBJ will be lower than the last iteration of the

parameter estimation. It seems that when this happens, NONMEM uses the default value (0) for OBJI for the data sent to that process, resulting in a lower OBJ. So, you can, in principle, rerun the model using the MSF and single process.

But, interestingly, while the OBJ reported in the outfile files seems to be wrong, NONMEM will still report SEE etc. Can the SEE values in this case be believed?




Mark Sale M.D.

Senior Vice President, Pharmacometrics
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 200
Durham, NC 27713

Phone (919)-973-0383

msale_at_nuventra.com
<br /><br />
ICON plc made the following annotations.
------------------------------------------------------------------------------
This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you
are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If
you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message.

Thank You,

ICON plc
South County Business Park
Leopardstown
Dublin 18
Ireland
Registered number: 145835


Received on Fri Feb 08 2019 - 23:20:39 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: nmusers-request@iconplc.com. Once subscribed, you may contribute to the discussion by emailing: nmusers@globomaxnm.com.