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Re: [NMusers] Log Transformed AST

From: William Denney <wdenney_at_humanpredictions.com>
Date: Mon, 22 Jul 2019 20:04:28 -0400

Hi Ranita,

Duy is correct. NONMEM is based on FORTRAN, so usually the mathematical fun=
ctions and operators are borrowed from FORTRAN: https://gcc.gnu.org/onlinedo=
cs/gfortran/LOG.html

Thanks,

Bill

> On Jul 22, 2019, at 19:49, Duy Tran <duytran16_at_gmail.com> wrote:
>
> If you desire to log transform by base 10 instead of e, use LOG10 in NONME=
M instead of LOG
>
>> On Mon, Jul 22, 2019 at 4:43 PM Ranita Kirubakaran <r.kirubakaran_at_unsw.ed=
u.au> wrote:
>> Dear all,
>>
>> I am a PhD student working on NONMEM as a new user. I am working on exter=
nal evaluation of some of the selected published population PK models. While=
 trying to implement one of the models in NONMEM, I realised that if I code l=
og-transformed aspartate aminotransferase (LAST) as LAST = LOG(AST), the s=
dtab output is giving me the In(AST) value instead of a LOG(AST) value. Was=
 wondering if NONMEM interprets all Log (x) as Log e (x) instead of Log 10 (=
x)?
>>
>> Thank you.
>>
>> Best Regards,
>> Ranita Kirubakaran
>> PhD Candidate
>>
>>
>> Ranita Kirubakaran
>>
>> PhD Candidate
>> St Vincent’s Clinical School | UNSW Sydney
>> Department of Clinical Pharmacology and Toxicology
>> Therapeutics Centre | Level 2 Xavier Building
>> St Vincent’s Hospital
>> 390 Victoria Street | Darlinghurst NSW 2010 | Australia
>> E r.kirubakaran_at_student.unsw.edu.au | P +61 (2) 8382 2199 | F +61 (2) 83=
82 2724
>>
>
>

Received on Mon Jul 22 2019 - 20:04:28 EDT

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