NONMEM Users Network Archive

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[NMusers] RE: Sample distribution of etas

From: Bauer, Robert <Robert.Bauer_at_iconplc.com>
Date: Wed, 13 Mar 2019 15:39:53 +0000

Tingjie:
In NONMEM the most efficient and versatile way of obtaining samples from the posterior distribution for any parameters you desire is that shown by example 8 in the intro7.pdf manual in the section: Example 8: Sample History of Individual Values in MCMC Bayesian Analysis

Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
Robert.Bauer_at_iconplc.com<mailto:Robert.Bauer_at_iconplc.com>
www.iconplc.com<http://www.iconplc.com/>

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On Behalf Of Tingjie Guo
Sent: Wednesday, March 13, 2019 5:30 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Sample distribution of etas

Dear NMusers,

When running simulation, I presume NONMEM samples etas from prior distribution N(0, omega^2), if I am correct? Is there a way to ask NONMEM to sample etas from posterior distribution (conditional on observed data)? Any ideas would be appreciated.

Yours sincerely,
Tingjie Guo
<br /><br />
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Received on Wed Mar 13 2019 - 11:39:53 EDT

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