NONMEM Users Network Archive

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Re: [NMusers] inclusion of covariates with $PRIOR

From: Jakob Ribbing <jakob.ribbing_at_pharmetheus.com>
Date: Fri, 17 May 2019 15:08:37 +0200

Dear Anna,

Just to answer quickly on the question directed to me: Yes, you =
understood it correctly.

To implement this in practice, since your NONMEM dataset only includes =
one level for the covariate (all subjects have the same covariate =
value), you will need to make a small addition to the SCM configuration =
file.
Lets assume DIS=1 is the covariate, where 1 codes for a new indication =
(which was not present in the legacy data used to generate the prior), =
or a new subpopulation, e.g. children/adolescents, where only adults =
where present in the legacy data.
You would then need to add this to the scm configuration file:
[code]
*:DIS-2=PARCOV=(1+THETA(1))
Other than that, it is also a little tricky to generate the NONMEM =
control stream with NWPRI on all parameters (of the base model).

PsN has an automatic function for generating this code (option to =
update_inits), but it may be good to check manually.

Best regards

Jakob


Jakob Ribbing, Ph.D.

Senior Consultant, Pharmetheus AB



Cell/Mobile: +46 (0)70 514 33 77

Jakob.Ribbing_at_Pharmetheus.com

www.pharmetheus.com <http://www.pharmetheus.com/>

Phone, Office: +46 (0)18 513 328

Uppsala Science Park, Dag Hammarskjölds väg 36B

SE-752 37 Uppsala, Sweden






Received on Fri May 17 2019 - 09:08:37 EDT

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