NONMEM Users Network Archive

Hosted by Cognigen

RE: [NMusers] Using evid 0 before dosing

From: Bill Denney <>
Date: Wed, 6 Nov 2019 10:12:06 -0500

Hi Carlos,

It is commonly used. For most datasets, there will be at least one
observation that occurs before dosing to estimate the baseline value, and in
almost every scenario, the modeling dataset should mirror the real world
actions. So, there is no issue with it, and usually you will have an EVID=0
before the first dose.



-----Original Message-----
From: <> On Behalf
Of Carlos ST
Sent: Wednesday, November 6, 2019 10:03 AM
Subject: [NMusers] Using evid 0 before dosing

Dear NMUsers,

I would like advice in the best practice to use evid 0 before dosing, which
is to say an observation just before a dosing (*to estimate the value in
that compartment just before dosing event).

Thank you,


Received on Wed Nov 06 2019 - 10:12:06 EST

The NONMEM Users Network is maintained by ICON plc. Requests to subscribe to the network should be sent to: Once subscribed, you may contribute to the discussion by emailing: