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Re: cumulative AUC

From: Leonid Gibiansky <lgibiansky>
Date: Fri, 8 Nov 2019 13:47:51 -0500

Negative CMT (in the data set) resets compartment amounts (CMT=-4 in
this case)
EVID = 4 resets all system, including A(4) (if washout time was long
and all compartments can be set to 0)
Also, it is easy to do post-processing, subtracting Cycle 1 AUC from
Cycle 1-2 AUC to get Cycle 2 AUC, etc.
Hope this helps

On 11/8/2019 12:59 PM, Sam Liao wrote:
> Dear nmusers,
> I have a question how to reset cumulative AUC in a $DES model, where
> DADT(4) is set up as cumulative AUC of C1.
> Because the study is a four way crossover study, the cumulative value of
> A(4) need to rest to zero before each subsequent treatments.
> However, NONMEM do not allow setting A(4) to zero in the statement of
> control stream.
> Is there any work around of this problem?
> Best regards,
> Sam Liao
> On 11/7/2019 7:17 AM, Farrell, Colm wrote:
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Received on Fri Nov 08 2019 - 13:47:51 EST

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