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Re: [NMusers] cumulative AUC

From: Ruben Faelens <ruben.faelens_at_gmail.com>
Date: Fri, 8 Nov 2019 19:52:06 +0100

Hi Sam,

Can't you simply dose with evid=4 (reset) into your auc compartment
(cmt=4)?


Op vr 8 nov. 2019 19:09 schreef Sam Liao <sliao_at_pharmaxresearch.com>:

> Dear nmusers,
>
> I have a question how to reset cumulative AUC in a $DES model, where
> DADT(4) is set up as cumulative AUC of C1.
>
> Because the study is a four way crossover study, the cumulative value of
> A(4) need to rest to zero before each subsequent treatments.
>
> However, NONMEM do not allow setting A(4) to zero in the statement of
> control stream.
>
> Is there any work around of this problem?
>
> Best regards,
>
> Sam Liao
> On 11/7/2019 7:17 AM, Farrell, Colm wrote:
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Received on Fri Nov 08 2019 - 13:52:06 EST

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