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Re: [NMusers] cumulative AUC

From: Leonid Gibiansky <lgibiansky_at_quantpharm.com>
Date: Fri, 8 Nov 2019 13:58:01 -0500

actually CMT=-4 turns compartment 4 off. It need to be turned on again,
see by the record with CMT=4 (positive), see

Plasma urine example

in Nonmem help

Leonid

On 11/8/2019 1:47 PM, Leonid Gibiansky wrote:
> Negative CMT (in the data set) resets compartment amounts (CMT=-4 in
> this case)
> EVID = 4 resets all system, including A(4)  (if washout time was long
> and all compartments can be set to 0)
> Also, it is easy to do post-processing, subtracting Cycle 1 AUC from
> Cycle 1-2 AUC to get Cycle 2 AUC, etc.
> Hope this helps
> Leonid
>
> On 11/8/2019 12:59 PM, Sam Liao wrote:
>> Dear nmusers,
>>
>> I have a question how to reset cumulative AUC in a $DES model, where
>> DADT(4) is set up as cumulative AUC of C1.
>>
>> Because the study is a four way crossover study, the cumulative value
>> of A(4) need to rest to zero before each subsequent treatments.
>>
>> However, NONMEM do not allow setting A(4) to zero in the statement of
>> control stream.
>>
>> Is there any work around of this problem?
>>
>> Best regards,
>>
>> Sam Liao
>>
>> On 11/7/2019 7:17 AM, Farrell, Colm wrote:
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>> --
>> Sam Liao
>>

Received on Fri Nov 08 2019 - 13:58:01 EST

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