NONMEM Users Network Archive

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Re: [NMusers] cumulative AUC

From: Matthew Fidler <matthew.fidler_at_gmail.com>
Date: Fri, 8 Nov 2019 13:18:05 -0600

Hi Sam,

Leonid is correct, you have to turn it off and then back on again.

https://nlmixrdevelopment.github.io/RxODE/articles/RxODE-event-types.html#t=
urning-off-compartments

shows a visual example.

Matt.

On Fri, Nov 8, 2019 at 1:12 PM Leonid Gibiansky <lgibiansky_at_quantpharm.com>
wrote:

> actually CMT=-4 turns compartment 4 off. It need to be turned on again,
> see by the record with CMT=4 (positive), see
>
> Plasma urine example
>
> in Nonmem help
>
> Leonid
>
> On 11/8/2019 1:47 PM, Leonid Gibiansky wrote:
> > Negative CMT (in the data set) resets compartment amounts (CMT=-4 in
> > this case)
> > EVID = 4 resets all system, including A(4) (if washout time was long
> > and all compartments can be set to 0)
> > Also, it is easy to do post-processing, subtracting Cycle 1 AUC from
> > Cycle 1-2 AUC to get Cycle 2 AUC, etc.
> > Hope this helps
> > Leonid
> >
> > On 11/8/2019 12:59 PM, Sam Liao wrote:
> >> Dear nmusers,
> >>
> >> I have a question how to reset cumulative AUC in a $DES model, where
> >> DADT(4) is set up as cumulative AUC of C1.
> >>
> >> Because the study is a four way crossover study, the cumulative value
> >> of A(4) need to rest to zero before each subsequent treatments.
> >>
> >> However, NONMEM do not allow setting A(4) to zero in the statement of
> >> control stream.
> >>
> >> Is there any work around of this problem?
> >>
> >> Best regards,
> >>
> >> Sam Liao
> >>
> >> On 11/7/2019 7:17 AM, Farrell, Colm wrote:
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Received on Fri Nov 08 2019 - 14:18:05 EST

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