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[NMusers] Stepwise covariate modeling

From: Singla, Sumeet K <sumeet-singla_at_uiowa.edu>
Date: Tue, 29 Oct 2019 14:00:29 +0000

Hi!

I am performing stepwise covariate modeling using PsN feature in Pirana. I =
am getting some covariates which are statistically reducing OFV significant=
ly, however, when I include those covariates in the PK model, the results I=
 am getting are exactly similar to what I am getting in my base model, i.e.=
 there is no difference in individual predictions or pop predictions or any=
 other diagnostic plots. So, does that mean I should move forward WITHOUT i=
ncluding those covariates as they don't seem to be explaining inter-individ=
ual variability despite scm telling me that they are statistically signific=
ant?

Regards,

Sumeet K. Singla
Ph.D. Candidate
Division of Pharmaceutics and Translational Therapeutics
College of Pharmacy | University of Iowa
Iowa City, Iowa
sumeet-singla_at_uiowa.edu<mailto:sumeet-singla_at_uiowa.edu>
518.577.5881



Received on Tue Oct 29 2019 - 10:00:29 EDT

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