NONMEM Users Network Archive

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Negative concentration from simulation

From: Nyein Hsu Maung <nyeinhsumaung2018>
Date: Wed, 3 Jun 2020 01:13:18 +0700

Dear NONMEM users,
I tried to simulate a new dataset by using a previously published pop pk mod=
el. Their model was described by combined error model for residual variabili=
ty. And after simulation, I have obtained two negative concentrations. I wou=
ld like to know if there is any proper way to handle those negative concentr=
ations or if there are some codings to prevent gaining negative concentratio=
ns. Thanks.

Best regards,
Nyein Hsu Maung

Received on Tue Jun 02 2020 - 14:13:18 EDT

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