NONMEM Users Network Archive

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Re: Negative concentration from simulation

From: Leonid Gibiansky <lgibiansky>
Date: Tue, 2 Jun 2020 14:25:21 -0400

you can treat it as any other value below quantification limit, and
either comment it out (if you do this with other BQLs) or use it (same
as other BQLs)

On 6/2/2020 2:13 PM, Nyein Hsu Maung wrote:
> Dear NONMEM users,
> I tried to simulate a new dataset by using a previously published pop pk model. Their model was described by combined error model for residual variability. And after simulation, I have obtained two negative concentrations. I would like to know if there is any proper way to handle those negative concentrations or if there are some codings to prevent gaining negative concentrations. Thanks.
> Best regards,
> Nyein Hsu Maung
Received on Tue Jun 02 2020 - 14:25:21 EDT

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